Why will a patient with Systemic Carnitine deficiency experience repeated episodes of hypoglycemia?

  1. Why will a patient with Systemic Carnitine deficiency experience repeated episodes of hypoglycemia?
  2. Why would there be steatosis (lipid accumulation) in th liver of a patient with Systemic Carnitine deficiency? Why will skeletal muscle carnitine content remain below normal despite high-dose carnitine therapy in this patient?
  3. Give at least 3 possible explanations for a false-negative result in a patient with G6PD deficiency?
  4. Distinguish in biochemical detail between peroxisomal ?-oxidation of fatty acids and mitochondrial ?-oxidation of fatty acids
  5. Distinguish in biochemical detail between ?-oxidation of saturated and unsaturated fatty acids

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